Scientific publications

Articles in Journals:

  1. Milosevic M, Stojanovic D, Simic V, Milicevic B, Radisavljevic A, Uskokovic P, Kojic M, A Computational Model for Drug Release from PLGA Implant, Materials, 11/12, 2018, doi: 10.3390/ma11122416
  2. Sossalla S, Meindl C, Fischer M, Lubnow M, Müller T, Maier L, Bail-Out Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy in a Patient With Takotsubo Cardiomyopathy-Induced Cardiogenic Shock, Circulation: Cardiovascular Interventions, 12/2, 2019, doi: 10.1161/circinterventions.118.007425
  3. Koshy A, Okwose N, Nunan D, Toms A, Brodie D, Doherty P, Seferovic P, Ristic A, Velicki L, Filipovic N, Popovic D, Skinner J, Bailey K, MacGowan G,. Jakovljevic Dj, Association between heart rate variability and haemodynamic response to exercise in chronic heart failure, Scandinavian Cardiovascular Journal, 53/2, 2019, doi: 10.1080/14017431.2019.1590629
  4. Parovic M, Okwose N, Bailey K, Velicki L, Fras Z, Seferovic P, MacGowan G, Jakovljevic Dj, NTproBNP is a weak indicator of cardiac function and haemodynamic response to exercise in chronic heart failure, ESC Heart Failure, 6/2, 2019, doi: 10.1002/ehf2.12424
  5. Kojic M, Milosevic M, Simic V, Geroski V, Ziemys A, Filipovic N, Ferrari M, Smeared multiscale finite element model for electrophysiology and ionic transport in biological tissue, Computers in Biology and Medicine, 108, 2019, doi: 10.1016/j.compbiomed.2019.03.023
  6. Mijailovich S, Prodanovic M, Vasovic L, Stojanovic B, Maric M, Prodanovic D, Powers J, Davis J, Geeves M, Regnier M, Modulation of Calcium Sensitivity and Twitch Contractions in Cardiac Muscle with Troponin-C Mutations: Simulations and Experiments, Biophysical Journal, 116/3, 2019, doi: 10.1016/j.bpj.2018.11.654
  7. Mijailovich S, Stojanovic B, Nedic DJ, Svicevic M, Geeves M, Irving T, Granzier H, Nebulin and titin modulate cross-bridge cycling and length-dependent calcium sensitivity, The Journal of General Physiology, 151/5, 2019, doi: 10.1085/jgp.201812165
  8. Piroddi N, Witjas-Paalberends ER, Ferrara C, Ferrantini C, Vitale G, Scellini B, J.M. Wijnker P, Sequiera V, Dooijes D, Remedios C, Schlossarek S, Ching Leung M, Messer A, Ward D, Biggeri A, Tesi C, Carrier L, Redwood C, Marston S, Van der Velden J, Poggesi C, The homozygous K280N troponin T mutation alters cross-bridge kinetics and energetics in human HCM, The Journal of General Physiology, 151/1, 2019, doi: 10.1085/jgp.201812160
  9. Vitale G, Lazzeri E, Costantini I, Giardini F, Mazzamuto G, Crocini C, Piroddi N, Scellini B, Pioner M, Ferrantini C, Tesi C, Pavone F, Sacconi L, Poggesi C, Advanced Morpho-Functional Analysis on Ventricular and Atrial Tissue Reveals Cross-Bridge Kinetics Alterations and Sarcomere Energetic Impairment in Hcm Patients, Biophysical Journal, 116/3, 2019, doi: 10.1016/j.bpj.2018.11.198
  10. Walklate J, Ujfalusi Z, Behrens V, King E, Geeves M, A micro-volume adaptation of a stopped-flow system; use with μg quantities of muscle proteins, Analytical Biochemistry, 581, 2019, doi: 10.1016/j.ab.2019.06.009
  11. Charman S, Okwose N, Maniatopoulos G, Graziadio S, Metzler T, Banks H, Vale L, MacGowan G, Seferović P, Fuat A, Deaton C, Mant J, Hobbs R, Jakovljevic DJ, Opportunities and challenges of a novel cardiac output response to stress (CORS) test to enhance diagnosis of heart failure in primary care: qualitative study, BMJ Open, 9/4, 2019, doi: 10.1136/bmjopen-2018-028122
  12. Gao X, Jakovljevic DJ, Beard D, Cardiac metabolic limitations contribute to diminished performance of the heart in aging, Biophysical Journal,  2019, doi: https://doi.org/10.1016/j.bpj.2019.06.026
  13. Joseph D. Powers, Kristina B. Kooiker, Allison B. Mason, Abigail E. Teitgen, Galina V. Flint, Jil C. Tardiff, Steven D. Schwartz, Andrew D. McCulloch, Michael Regnier, Jennifer Davis, Farid Moussavi-Harami Targeting the tension-time integral of the cardiac twitch prevents dilated cardiomyopathy in murine hearts. https://doi.org/10.1172/jci.insight.142446 In Press.
  14. Doran MH, Pavadai E, Rynkiewicz MJ, Walklate J, Bullitt E, Moore JR, Regnier M, Geeves MA, Lehman W. Cryo-EM and Molecular Docking Shows Myosin Loop 4 Contacts Actin and Tropomyosin on Thin Filaments. Biophys J. 2020 119:821-830. doi: 10.1016/j.bpj.2020.07.006. PMID: 32730789; PMCID: PMC7451941. https://insight.jci.org/articles/view/142446?utm_campaign=cover-page&utm_content=short_url&utm_medium=pdf&utm_source=content
  15. Okwose, N.C., Avery, L., O’Brien, N. et al.Acceptability, Feasibility and Preliminary Evaluation of a Novel, Personalised, Home-Based Physical Activity Intervention for Chronic Heart Failure (Active-at-Home-HF): a Pilot Study. Sports Med – Open 5, 45 (2019). https://doi.org/10.1186/s40798-019-0216-x https://sportsmedicine-open.springeropen.com/articles/10.1186/s40798-019-0216-x
  16. Dejana Popovic MD, Ross Arena PT, Djordje Jakovljevic, Arsen Ristic MD, Marco Guazzi MD,   Ventricular arrhythmias not meeting criteria for terminating cardiopulmonary exercise testing stratify prognosis and disease severity in heart failure of preserved, midrange, and reduced ejection fraction, Clinical Cardiology, Volume 43, Issue7, July 2020, Pages 698-705 https://onlinelibrary.wiley.com/doi/10.1002/clc.23367
  17. Maria Tafelmeier, Andrea Baessler, Stefan Wagner,  Bernhard Unsoeld,  Andrej Preveden,  Fausto Barlocco,  Alessia Tomberli,  Dejana Popovic,  Paul Brennan,  Guy A. MacGowan,  Arsen Ristic,  Lazar Velicki,  Iacopo Olivotto,  Djordje G. Jakovljevic,  Lars S. Maier Design of the SILICOFCM study: Effect of sacubitril/valsartan vs lifestyle intervention on functional capacity in patients with hypertrophic cardiomyopathy, Volume43, Issue5, May 2020, Pages 430-440 https://doi.org/10.1002/clc.23346
  18. Mijailovich, S.M.; Prodanovic, M.; Irving, T.C. Estimation of Forces on Actin Filaments in Living Muscle from X-ray Diffraction Patterns and Mechanical Data. Int. J. Mol. Sci. 2019, 20, 6044. https://www.mdpi.com/1422-0067/20/23/6044

Other:

  1. Vera C, Johnson C, Walklate J, Adhikari A, Ujfalusi Z, Svicevic M, Mijailovich S, Combs A, Langer S, Ruppel K, Spudich J, Leinwand L, Geeves M, Pediatric and adult-onset HCM mutations in the myosin motor domain have similar properties, BioRxiv, 2019, doi: doi.org/10.1101/622738
  2. Johnson C, Walklate J, Svicevic M, Mijailovich S, Vera C, Karabina A, Leinwand L, Geeves M, The ATPase cycle of Human Muscle Myosin II Isoforms: Adaptation of a single mechanochemical cycle for different physiological roles, bioRxiv, 2019, doi: https://doi.org/10.1101/672030

Thesis/dissertation:

  1. Sacco F, Quantification of the influence of detailed endocardial structures on human cardiac haemodynamics and electrophysiology using HPC, 2019.

Conferences and workshops:

  • Regnier, Geeves & Poggesi, Invited Lectures, European Muscle Conference, August 31 – September 3, 2018, Budapest, Hungary
  • Initial benchmarking results of the SBG Graph Genome Pipeline and cardiomyopathy graph reference genome that is developed for the SILICOFCM was presented with an oral presentation at TRANSCARDIO 18. A RES Scientific Workshop, Barcelona Supercomputing Center (BSC), Spain, December, 18-19, 2018.
  • Mijailovich S, Prodanovic M, Vasovic L, Stojanovic B, Maric M, Prodanovic D, Powers J, Davis J, Geeves M, Regnier M, Modulation of Calcium Sensitivity and Twitch Contractions in Cardiac Muscle with Troponin-C Mutations: Simulations and Experiments, Annual meeting of the Biophysical Society, Baltimore, USA, March, 02-06, 2019
  • Okwose NC, Avery L, O’Brien N, Cassidy S, Charman S, Bailey K, MacGowan GA, Jakovljevic DG, A personalised home-based physical activity intervention for chronic heart failure: do physiological changes correspond with patients experience? American Heart Association Epidemiology, Prevention, Lifestyle and Cardiometabolic Health Annual Conference, Houston, Texas, March, 05-08, 2019
  • Walkate J, Vera C, Johnson C, Adhikari A, Svicevic M, Mijailovich S, Combs A, Langer S, Ruppel K, Spudich J, Leinwand L, Geeves M, How Juvenile Hypertrophic Cardiomyopathy (HCM) mutations affect the kinetics of human beta myosin, Alpbach Motors Workshop, Myosin and Muscle and Other Motors, March 2019, Austria
  • Metzler T, Okwose N, Hanssen H, Deiseroth A, MacGowan GA, Jakovljevic DG, Arterial Stiffness in younger patients with rheumatoid disease is equivalent to that of older patients with chronic heart failure, European Society of Cardiology EuroPrevent Congress, Lisbone, Portugal, April, 11-13, 2019
  • Aguado-Sierra J, Computers simulating the heart: How close are we to recreating physiology? Cardiovascular Seminar Series, The University of Manchester, UK, May, 02, 2019
  • Sacco F, Butakoff C, Aguado-Sierra J, Vázquez M, Iles T, Iaizzo P, Anatomically accurate electrophysiology simulations of the human heart, with application to scarred tissue, LBBB and CRT, ASME 2019 V&V Symposium, Las Vegas, USA, May, 13-17, 2019
  • Mijailovich S, Prodanovic M, Stojanovic B, Powers J, Davis J, Geeves M, Regnier M, The effects of sarcomeric protein mutations leading to familial cardiomyopathy: integrated modeling of multiscale cardiac system. Presented at workshop: Modelling in bioengineering and bioinformatics, Prof. Nenad Filipovic – organizer, IEEE BHI-BSN 2019 International Conference on Biomedical and Health Infotmatics, USA, May, 19-22, 2019
  • Kojic M, Milosevic M, Simic V, Milicevic B, Geroski V, Filipovic N, Our smeared FE model for electrophysiology coupled with heart muscle mechanics, IEEE BHI-BSN 2019 International Conference on Biomedical and Health Infotmatics, USA, May, 19-22, 2019
  • Fatrin S, Okwose NC, Bailey K, Velicki L, Ninkovic V, Seferovic PM, MacGowan GA, Jakovljevic DG. Relationship between functional capacity, haemodynamic response to exercise and quality of life in chronic heart failure. European Society of Cardiology Heart Failure Association Annual Congress, Athens, Greece, May, 25-28, 2019
  • N. Ilic Raicevic, L. Lenhardt Ackovic, V. Kovacevic, S. Stojanovic, J. Randjelovic, A. S. Yavuz, M. Lazarevic, M. Mattioni From genomics data to multiscale – Portable pipeline for extracting cardiomyopathy specific parameters, ESHG 2020 Conference, https://2020.eshg.org/
  • Pezoulas,V. C., Tachos, N. S., and Fotiadis, D. I., “Generation ofVirtual Patients for in Silico Cardiomyopathies Drug Development,” In 2019 IEEE19th International Conference on Bioinformatics and Bioengineering (BIBE), pp.671-674, 2019. https://zenodo.org/record/4050523#.X3Hs72gzaUk
  • Pezoulas,V. C., Grigoriadis, G. I., Tachos, N. S., Barlocco, F.,Olivotto, I., & Fotiadis, D. I, “Generation of virtual patient data forin-silico cardiomyopathies drug development using tree ensembles: a comparativestudy,” In 2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), pp. 5343-5346, 2020. https://zenodo.org/record/4050541#.X3HzxmgzaUk
  • S.M. Mijailovich, M. Prodanovic, C. Poggesi, M. Regnier M.A. and Geeves, Effect of myosin isoform on mechanics in intact cardiac trabeculae from Mice, rats and humans, Bio Physical Society annual meeting 2020. (Poster presentation)
  • S.M. Mijailovich, M.A. Geeves, M. Regnier, C. Poggesi, T.C. Irving, M. Prodanovic and B. Stojanovic Multiple Scale Approaches for Complex Diseases in Muscle VPH2020 Conference, Paris 26-28 August 2020
  • Sustersic T, Anic M, Filipovic N, Heart left ventricle segmentation in ultrasound images using deep learning, 2020 IEEE 20th Mediterranean Electrotechnical Conference (MELECON), 16-18 June 2020, Palermo, Italy, https://ieeexplore.ieee.org/document/9140527/authors#authors
  • Filipovica N, Djorovic S, Geroski V,Milosevic M, Kojic M, In Silico heart model: electromechanical coupling, VPH2020 Conference, 26-28 August 2020, Paris, France, Link
  • Milosevic M, Milicevic B, Simic V, Geroski V, Djorovic S, Kojic M, Filipovic N, Application of electro-mechanical model for investigation of human heart behaviour, EMBEC2020 8th European Medical and Biological Engineering Conference, 29 November – 3 December 2020, Portorož, Slovenia
  • Simic V, Milosevic M, Milicevic B, Geroski V, Kojic M, Filipovic N, Application of smeared modeling concept and Holzapfel material model for investigation of human heart properties, EMBEC2020 8th European Medical and Biological Engineering Conference, 29 November – 3 December 2020, Portorož, Slovenia
  • Milicevic B, Stojanovc B, Ivanovic M, Filipovic N, The Recurrent Neural Networks for Muscle Stress Prediction in Finite Element Analysis, EMBEC2020 8th European Medical and Biological Engineering Conference, 29 November – 3 December 2020, Portorož, Slovenia
  • Filipovic N, Milosevic M, Djorovic S, Geroski V, Gacic M, Saveljic I, Stojanovic B, Ivanovic M, Kojic M, In Silico clinical trials for cardiovascular disease, EMBEC2020 8th European Medical and Biological Engineering Conference, 29 November – 3 December 2020, Portorož, Slovenia
  • Filipovic N, Saveljic I, Milosevic M, Geroski V, Milićevic B, Simic V, Kojic M, In silico clinical trials for heart disease, WEBINAR – MATHEMATICS FOR HUMAN FLOURISHING IN THE TIME OF COVID-19 AND POST COVID-19, 21 October 2020, Niš, Serbia
  • Stojanovic B, Prodanovic M, Prodanovic D, Mijailovich S, FINITE ELEMENT SOLUTION FOR CARDIAC MUSCLE CONTRACTION IN WHOLE HEART, 14th World Congress in Computational Mechanics (WCCM) ECCOMAS Congress 2020, 11-15 January, 2021, Paris, France, Link
  • Prodanovic M, Prodanovic D, Stojanovic B, Poggesi C, Regnier M, Geeves M, Mijailovich S, COMPARATIVE SIMULATIONS OF INTACT CARDIAC MUSCLE RESPONSES FROM MICE, RATS AND HUMANS: THE EFFECT OF MYOSIN ISOFORMS, 14th World Congress in Computational Mechanics (WCCM) ECCOMAS Congress 2020, 11-15 January, 2021, Paris, France, Link
  • Kojic M, COMPOSITE SMEARED FINITE ELEMENT – A REVIEW OF ADVANCES IN MULTISCALE MODELLING OF COUPLED PHYSICAL FIELD AND MECHANICS OF BIOLOGICAL SYSTEMS, 14th World Congress in Computational Mechanics (WCCM) ECCOMAS Congress 2020, 11-15 January, 2021, Paris, France, Link
  • Kojic M, Simic V, Milosevic M, SMEARED METHODOLOGY IN FINITE ELEMENT MODELING MECHANICAL PROBLEMS IN COMPOSITE MEDIA, 14th World Congress in Computational Mechanics (WCCM) ECCOMAS Congress 2020, 11-15 January, 2021, Paris, France, Link
  • Milicevic B, Milosevic M, Filipovic N, Kojic M, IMAGE-BASED NUMERICAL SIMULATION OF HEART WITH PRESCRIBED DISPLACEMENTS ON THE HEART SURFACE, 14th World Congress in Computational Mechanics (WCCM) ECCOMAS Congress 2020, 11-15 January, 2021, Paris, France, Link
  • Geroski V, Milosevic M, Filipovic N, Kojic M, COUPLED CSFE – ORD NUMERICAL MODEL FOR HEART ELECTRO-MECHANICS, 14th World Congress in Computational Mechanics (WCCM) ECCOMAS Congress 2020, 11-15 January, 2021, Paris, France, Link